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Keep track of Carefully (one)pentobarbital will reduce the level or result of osilodrostat by influencing hepatic/intestinal enzyme CYP3A4 metabolism.fentanyl iontophoretic transdermal technique and pentobarbital the two increase sedation. Prevent or Use Alternate Drug. Restrict use to people for whom alternative therapy solutions are insufficient
Minor (1)pentobarbital will minimize the level or effect of paclitaxel protein bound by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Unfamiliar.
pentobarbital will lessen the level or effect of fesoterodine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.
Barbiturates could cause fetal harm when administered into a pregnant girl; retrospective, scenario-controlled reports have prompt a relationship concerning maternal usage of barbiturates and a greater-than-predicted incidence of fetal abnormalities
pentobarbital will lessen the extent or impact of methadone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.
pentobarbital will minimize the extent or outcome of estropipate check here by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
pentobarbital will lower the extent or influence of fentanyl transdermal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Carefully. Coadministration of fentanyl with CYP3A4 inducers could lead on into a lower in fentanyl plasma concentrations, deficiency of efficacy or, quite possibly, improvement of a withdrawal syndrome in a client who's got produced physical dependence to fentanyl.
This drug may possibly raise the metabolism of estradiol when administered concurrently; patients on oral contraceptives are getting to be pregnant when concurrently handled with antiepileptic drugs; propose an alternate contraceptive method to Ladies having this drug
Caution when discontinuing CYP3A4 inducers that are coadministered with hydrocodone; plasma concentrations of hydrocodone could raise and may lead to likely deadly respiratory depression
Contraindicated (1)pentobarbital will minimize the level or impact of doravirine by impacting hepatic/intestinal enzyme CYP3A4 metabolism.
pentobarbital will minimize the extent or influence of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
pentobarbital will lessen the extent or impact of estradiol vaginal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.
pentobarbital will reduce the extent or outcome of finasteride by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Mysterious.